1. 연제 및 연사:
'Protein biochips: construction, signalling, and application'
윤 현철 박사 - ETRI 반도체 원천기술연구소
'Surface enhanced phenomenon: Applications to multi-channel
imaging sensor system'
표현봉 박사 - ETRI 반도체 원천기술연구소
2. 일시: 2002년 11월 7일(목요일) 오후 2시
3. 장소: 공과대학 5호관 2층 세미나실
4. Host(문의 및 연사 면담 주선):
의과대학 해부학교실 이승원 교수 (062-220-4205)
5. 발표 내용과 연사 약력은 다음과 같습니다.
Protein biochips: construction, signalling, and application
윤현철 (hcyoon@etri.re.kr)
There has been an increasing demand for efficient analytical tools for immunoassays in the fields of clinical analysis and biochemical studies. Based on the requirement, a new scientific field in bioassay has been emerging, linking bioanalytical techniques with microelectronics technology. Especially, immuno- or affinity-sensing biochip technology, registering biospecific interactions such as antigen-antibody, ligand-receptor and protein-protein recognition reactions, is under great demand in terms of assay automation and throughput/output. Additionally, recent completion of human genome project (HGP) and flourishing genomics opened a new research field of proteomics, making the development of affinity-sensing techniques with biochips more important.
Objectively, research trends in protein biochips area are mainly with two directions consisting the design of affinity surfaces presenting desired characteristics such as useful surface functionality, adequate immobilization density, biocompatibility, resistance to nonspecific binding, etc., and the development of novel transduction techniques, particularly stressing parallel sensing with array-type sensors. Based on the viewpoint, an overview of protein biochip technology with an in-depth summary of model studies of our group will be given in the talk.
1994 KAIST Dept. Biotechnology 학사
2000 KAIST Dept. Biological Sciences 석사, 박사
2000- 2001 KAIST 자연과학연구소 Postdoctoral fellow
2001- 현재 ETRI 원천기술연구소 바이오소자그룹 선임연구원
Surface enhanced phenomena: Applications to multi-channel
imaging sensor systems
Hyeon-Bong Pyo, Dr. rer. nat.
E-mail: pyo@etri.re.kr
Abstract
Molecular binding and interaction within the enhanced electric field induced by surface plasmon and by metal clusters on the surface gives us a good opportunity to detect the biocognitive binding, in sub-picomolar scale.
Highly resonant sensor chip and imaging system such as surface plasmon resonance (SPR) sensor/imager, surface-enhanced Raman scattering (SERS) as well as surface-enhanced fluorescence (SEF) therefore will be the effective means to detect the bindings of nucleic acids, enzymes and proteins.
In this study, we have developed a surface plasmon and guided mode imaging system and the images of photoresist and of SAM patterns on gold-coated sensor chip were obtained, for the thickness level of mm down to nm range.
1996 ~ 현재: ETRI 반도체.원천기술연구소
1995: 박사/ Univ. Hamburg(Germany)/이론 핵 물리(Theo. Kernphysik)
1991: Diplom/ Univ. Hamburg(Germany)/물리학과
1986: 학사/ 서울대학교 자연대학 물리학과